Author:
Furushima Daisuke,Kawano Shoko,Ohno Yuko,Kakehashi Masayuki
Abstract
Background:
The novel influenza A (H1N1) pdm09 (A/H1N1pdm) pandemic of 2009-2010 had a great impact on society.
Objective:
We analyzed data from the absentee survey, conducted in elementary schools of Oita City, to evaluate the A/H1N1pdm pandemic and to estimate the basic reproductive number (R0 ) of this novel strain.
Method:
We summarized the overall absentee data and calculated the cumulative infection rate. Then, we classified the data into 3 groups according to school size: small (<300 students), medium (300–600 students), and large (>600 students). Last, we estimated the R0 value by using the Susceptible-Infected-Recovered (SIR) mathematical model.
Results:
Data from 60 schools and 27,403 students were analyzed. The overall cumulative infection rate was 44.4%. There were no significant differences among the grades, but the cumulative infection rate increased as the school size increased, being 37.7%, 44.4%, and 46.6% in the small, medium, and large school groups, respectively. The optimal R0 value was 1.33, comparable with that previously reported. The data from the absentee survey were reliable, with no missing values. Hence, the R0 derived from the SIR model closely reflected the observed R0 . The findings support previous reports that school children are most susceptible to A/H1N1pdm virus infection and suggest that the scale of an outbreak is associated with the size of the school.
Conclusion:
Our results provide further information about the A/H1N1pdm pandemic. We propose that an absentee survey should be implemented in the early stages of an epidemic, to prevent a pandemic.
Publisher
Bentham Science Publishers Ltd.
Reference31 articles.
1. Itoh Y, Shinya K, Kiso M, et al.
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses.
Nature
2009;
460
: 1021-5.
2. World Health Organization..
Statement to the press by WHO Director-General Dr Margaret Chan.
[cited 2016 October 10] Available from:
http://who.int/mediacentre/news/statements/2009/ h1n1_pandemic_phase6_20090611/en/
2009.
11 June 2009
3. Viboud C, Miller M, Olson D, Osterholm M, Simonsen L.
Preliminary estimates of mortality and years of life lost associated with the 2009 A/H1N1 pandemic in the US and comparison with past influenza seasons.
PLoS Curr
2010;
2
: RRN1153.
4. Lessler J, Reich NG, Cummings DA, et al.
Outbreak of 2009 pandemic influenza A (H1N1) at a New York City school.
N Engl J Med
2009;
361
: 2628-36.
5. Nishiura H.
Case fatality ratio of pandemic influenza.
Lancet Infect Dis
2010;
10
: 443-4.
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