Affiliation:
1. Department of Inorganic and Analytical Chemistry, University of Szeged, Dom ter 7, H-6720 Szeged, Hungary
Abstract
Biospeciation of essential and toxic metal ions, metal complexes with biological or
medicinal activity are discussed in the paper in order to emphasize the importance of the distribution
of metal ions in biological milieu. The exact knowledge of the chemical species present
in the different organs/compartments/fluids/cells may provide essential information about
the pharmacokinetic properties and the biological effect of the metal ion or the drug candidate
metal complex. The transport of essential and toxic metal ions in the blood serum is discussed
first, which is followed by the description of biodistribution of several important metal complexes
with medicinal interest such as (i) anticancer, (ii) insulin-enhancing and (iii) MRI contrast
agents in biological fluids.
Funder
Hungarian Scientific Research Fund
National Research, Development and Innovation Office-NKFI
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
14 articles.
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