A Simple and Efficient Protocol for the Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-Ones Catalyzed by Succinic Acid Using Water as Green Reaction Medium-Reference-Cited by-同舟云学术

A Simple and Efficient Protocol for the Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-Ones Catalyzed by Succinic Acid Using Water as Green Reaction Medium

Published:2021-02 Issue:2 Volume:18 Page:83-87
ISSN:1570-1786
Container-title:Letters in Organic Chemistry
language:en
Short-container-title:LOC

Author:

Ghogare Ramesh S.¹^ORCID,Patankar-Jain Kalpana¹^ORCID,Momin Sana Amir Hamzah¹^ORCID

Affiliation:

1. Department of Chemistry, B.N.N. College Bhiwandi, Dist-Thane-421305,India

Abstract

A simple and efficient protocol has been established to the synthesis of 3,4-disubstituted isoxazol-5(4H)-ones via Knoevenagel condensation reaction. In this synthesis, succinic acid was used as an inexpensive catalyst and water as a green reaction medium. This method is useful for the preparat ion of various derivatives of 3,4-disubstituted isoxazol-5(4H)-ones in excellent yields.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

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