Affiliation:
1. Department of Chemistry, Faculty of Science, Shahrekord University, Shahrekord, Iran
2. School of Chemistry, Damghan University, Damghan, Iran
3. Department of Chemistry, Faculty of Science, Shahrekord University, Shahrekord, Iran;
Abstract
Abstract:
The efficient, straightforward, and green procedure was established in the direction of synthesis of 4-arylmethylene-3-methylisoxazol-5(4H)-one derivatives using the malic acid, which acted as
the catalyst for the three-component heterocyclization reaction. In this reaction, aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and ethyl acetoacetate/ethyl benzoylacetate were applied as the
reactants. The reaction was optimized to attain the best conditions for the synthesis of target heterocyclic compounds in a single step route. The best results were obtained from optimization experiments
using 10 mol% malic acid as the catalyst, water solvent, and 50ºC temperature. The noticeable features
of this process are the simplicity of the experimental procedure, the easy separation of the pure compounds from the product mixture, the simplicity of operation, avoidance of any hazardous organic solvents, no use of chromatographic purification techniques, clean reaction profiles, high yields, relatively
short reaction time, and eco-friendliness
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
8 articles.
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