Microwave-Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents
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Published:2018-12-04
Issue:1
Volume:16
Page:66-75
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ISSN:1570-1786
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Container-title:Letters in Organic Chemistry
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language:en
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Short-container-title:LOC
Author:
McGown Andrew1, Ragazzon-Smith Abby1, Hadfield John A.1, Potgetier Herman2, Ragazzon Patricia A.3
Affiliation:
1. Biomedical Research Centre, Environment and Life Sciences, University of Salford, Salford, United Kingdom 2. School of Science and the Environment, Manchester Metropolitan University, Manchester, United Kingdom 3. School of Pharmacy, Keele University, Staffordshire, United Kingdom
Abstract
In this study, we describe a microwave-based click chemistry method used to prepare a family
of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked
through a triazole ring. The compounds were easily synthesized and purified in high yields. The bisflavonoids
were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several
analogues showed to have anticancer activity with IC50 values in the range of 20-60 μM. Flavonoids
are known for their anticancer properties and this method provides the basis for new medicinal structures.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
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