Affiliation:
1. Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, China
2. Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
3. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Abstract
Abstract:
The human gut is a complex but stable micro-ecosystem in which the intestinal microbiota
play a key role in human health, the health of the intestine and also affect the ability of the
host to metabolize nutrients. Intestinal microbiota can affect human physiological functions by
regulating host metabolism, immunity and intestinal barrier function. Dysbiosis in the intestinal
microbiota is a crucial stimulus for the development of various diseases, which is associated with
a variety of diseases in the body. The composition and function of intestinal microbiota depend on
the host’s physiological status, genetic makeup, dietary habits, age, and environment, which are
the risk factors for obesity, diabetes, cardiovascular diseases and tumors. Polyphenols are important
plant secondary metabolites with many physiological functions like anti-oxidation, antitumor,
bacteriostasis, cardiovascular and cerebrovascular prevention, and protection of liver and
kidney and so on. A large number of studies have confirmed the benefits of dietary polyphenols to
human health. Polyphenols and their associated metabolites affect intestinal health and the balance
of intestinal microbiota by stimulating the growth of beneficial bacteria and inhibiting the
proliferation of pathogens. This review aims to update the current knowledge and highlight how
the bioactivities of polyphenols can modulate the intestinal microbiota and regulate the mechanisms
of the microbiota, providing a theoretical basis and reference for the scientific and overall
use of polyphenols to prevent and treat intestinal diseases and maintain human intestinal health.
Funder
Key R & D Project in Shandong Province, China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
3 articles.
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