Affiliation:
1. Department of Pharmacy, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science and Technology, Wuhan 430081, China
2. Department of Pharmacy, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Abstract
In recent years, marine-derived Penicillium fungi have received remarkable interest as a
valuable source of novel natural products encompassing diverse chemical structures and bioactive
properties. Mangroves, sediments, algae, and sponges are the four main sources of marine-derived
Penicillium fungi. As of 2014, more than 390 novel natural products have been isolated from the marine-
derived Penicillium fungi, mainly including polyketides, alkaloids, terpenoids, and macrolides.
Biological investigations have shown that these compounds possess antimicrobial, anti-inflammatory,
cytotoxic, and other activities with potential applications in new drug development. To provide an
updated catalog of this field, our mini-review summarized the origins, structures, and bioactivities of
188 secondary metabolites from marine-derived Penicillium fungi based on bioactivities classification
published from 2015 to 2020.
Funder
Youth Innovative Training Fund for College Students of Hubei province
Natural Science Foundation of Hubei province
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
26 articles.
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