Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035

Author:

Xu Xiuli1,Dong Yifei2,Yang Jinpeng1,Wang Long3ORCID,Ma Linlin4,Song Fuhang2ORCID,Ma Xiaoli5

Affiliation:

1. Key Laboratory of Marine Mineral Resources and Polar Geology, Ministry of Education, School of Ocean Sciences, China University of Geosciences, Beijing 100083, China

2. Key Laboratory of Geriatric Nutrition and Health, Ministry of Education of China, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China

3. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

4. Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane 4111, Australia

5. School of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, China

Abstract

Two new polyketide derivatives, penirubenones A and B (1 and 2), and two naturally rare amino-bis-tetrahydrofuran derivatives, penirubenamides A and B (3 and 4), together with nine known compounds (5–13) were isolated from the marine-derived fungus Penicillium rubens BTBU20213035. The structures were identified by HRESIMS and 1D and 2D NMR analyses, and their absolute configurations were determined by a comparison of experimental and calculated electronic circular dichroism (ECD) spectroscopy and 13C NMR data. We found that 6 exhibited antibacterial activity against Staphylococcus aureus, with an MIC value of 3.125 μg/mL, and 1 and 2 showed synergistic antifungal activity against Candida albicans at 12.5 and 50 μg/mL with 0.0625 μg/mL rapamycin.

Funder

Guangxi Key Laboratory of Beibu Gulf Marine Resources, Environment and Sustainable Development

Publisher

MDPI AG

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