Affiliation:
1. Department of Biomolecular Chemistry, Faculty of Medicine, Medical University of Lodz, 92-215 Lodz,Poland
Abstract
:
Naturally occurring peptides found in the human skin can serve particular biological activities
and play roles as signaling molecules of various physiological processes such as homeostasis,
growth, defense or immunity. Their great biological activity resulted in a growing interest in the
pharmaceutical industry. Researchers consider peptides either promising compounds with potential
application for human diagnosis, therapy or cosmetics. Peptides are becoming interesting cosmetic
ingredients with the functions to reduce premature skin aging, improve the barrier function of skin,
moisturize the skin, protect it from UV damage, and anti-inflammatory properties that alleviate acne
and irritation. Till now, peptides of different origins were investigated in formulation developed to
enhance collagen or elastin production, increase fibroblast proliferation, improve wound healing or
skin condition. Most of them are obtained by chemical synthesis or by partial digestion of animal
proteins. Short and easily synthesized peptides with alternative amino acid sequence, and combinations
have created a new field of molecules inspired by nature and implemented in the cosmetic
industry. Nowadays, peptides are cheaper and easier to produce in large quantities. The efficient
process development methods allow obtaining nearly unlimited sequences, which makes them functionally
preferred. Generally, cosmetic peptides are categorized as carrier peptides, neurotransmitter-
affecting peptides, enzyme inhibitor peptides and signal peptides. The use of signal peptides in
cosmetics increased over a few years. These molecules trigger a signaling cascade and stimulate
fibroblast collagen production, the proliferation of elastin, fibronectin, laminin, etc. Thus, a literature
search on a topical application of the most common signal peptides; and their current status in
the cosmetic industry was carried out.
Funder
Medical University of Lodz
Publisher
Bentham Science Publishers Ltd.
Subject
Cell Biology,Molecular Biology,Biochemistry,General Medicine
Cited by
9 articles.
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