Affiliation:
1. I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, MINISTRY OF HEALTH OF UKRAINE, TERNOPIL, UKRAINE
Abstract
The aim: to find out the effect of a two-hour tourniquets ischemia of the limb and acute blood loss on systemic disorders of the body in the postperfusion period.
Materials and methods: The experiments were performed on 96 nonlinear male rats weighing 200-220 g. All experiments were performed under sodium thiopental anesthesia.
In the first experimental group, two-hour tourniquets limb ischemia was simulated. In the second experimental group, acute blood loss was modeled. In the third experimental
group, these lesions were combined. In 1 and 2 hours, as well as in 1, 7 and 14 days, the biliary function of the liver was determined in the experimental animals.
Results: Two-hour tourniquets ischemia of the limb in the reperfusion period compared with the control was accompanied by a significant decrease in the rate of bile excretion,
which reached a minimum value in 3 h – 1 day of the experiment and returned to the control level in 14 days. After the simulation of acute blood loss, the rate disturbance of
bile excretion became significantly greater in all observation periods. The complication of acute ischemia-limb reperfusion caused a greater decrease in the rate of bile excretion
with a maximum in 1 day of the experiment. Under these conditions, at 1, 7, and 14 days, the indicator was statistically significantly lower than in the other study groups.
Conclusions: In the case of acute blood loss, complicated by two-hour tourniquets ischemia of the limb, the reperfusion period is accompanied by a summation of the negative
impact of blood loss, ischemia and reperfusion of the limb on the functional state of the liver, which is a significant decrease in the rate of bile excretion with a maximum in 1
day, which further increases, but up to 14 days does not reach the level of control.
Reference11 articles.
1. 1. Global Terrorism Index. – Accessed: http://economicsandpeace.org/wp-content/uploads/2015/11/2015-Global-Terrorism-Index-Report.pdf.
2. 2. Elster E.A., Frank K.B., Todd E.R. Implications of Combat Casualty Care for Mass Casualty Events. JAMA. 2013;310(5):475-476.
3. 3. Efficacy of Prehospital Application of Tourniquets and Hemostatic Dressings To Control Traumatic External Hemorrhage DOT HS 811 999b. Washington, DC: National Highway Traffic Safety Administration. 2014:2-3.
4. 4. Clasper J.C., Brown K.V., Hill P. Limb complications following pre-hospital tourniquet use. J R Army Med Corps. 2009;155(3):200-202.
5. 5. Televiak A. T. Dynamika pokaznykiv perekysnoho okyslennia lipidiv ta antyoksydantnoho zakhystu v m'iazovii tkanyni zadnikh kintsivok shchuriv pry rozvytku ishemichno-reperfuziinoho syndromu (eksperymentalne doslidzhennia) [Indicator dynamics of lipid peroxidation and antioxidant protection in rat muscular tissue of hind limbs in the development of ischemic-reperfusion syndrome (experimental study)]. Achievements of clinical and experimental medicine. 2018;3(35):132-139. (In Ukrainian).
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献