The concept of thromboinflammation underlying thrombotic complications, tumor progression and metastasis in gynecological cancer patients-Reference-Cited by-同舟云学术

The concept of thromboinflammation underlying thrombotic complications, tumor progression and metastasis in gynecological cancer patients

Published:2024-09-12 Issue:4 Volume:18 Page:450-463
ISSN:2500-3194
Container-title:Obstetrics, Gynecology and Reproduction
language:
Short-container-title:Akušerstvo, ginekologiâ i reprodukciâ

Author:

Makatsariya A. D.¹^ORCID,Slukhanchuk E. V.¹^ORCID,Bitsadze V. O.¹^ORCID,Solopova A. G.¹^ORCID,Khizroeva J. Kh.¹^ORCID,Ashrafyan L. A.²^ORCID,Serov V. N.²^ORCID,Voynovskiy A. Е.³^ORCID,Ungiadze J. Yu.⁴^ORCID,Lazarchuk A. V.¹^ORCID,Tretyakova M. V.¹^ORCID,Makatsariya N. A.¹^ORCID,Salnikova P. V.¹^ORCID,Gashimova N. R.¹^ORCID,Grigoreva K. N.¹^ORCID,Zakashansky K. L.⁵^ORCID,Elalamy I.⁶^ORCID,Gris J.-C.⁷^ORCID

Affiliation:

1. Sechenov University

2. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Health Ministry of Russian Federation

3. Vorokhobov City Clinical Hospital № 67, Moscow Healthcare Department

4. Shota Rustaveli Batumi State University

5. Icahn School of Medicine at Mount Sinai

6. Sechenov University; Medicine Sorbonne University; Hospital Tenon

7. Sechenov University; University of Montpellier

Abstract

The results of recent studies show that tumor biology, coagulation activation, and inflammatory reactions profoundly contribute to the thrombosis pathogenesis in cancer as well as tumor progression, metastasis, and developing chemoresistance. Cancer is an independent predictor of thrombosis. During carcinogenesis, tumor cells express proinflammatory cytokines, proangiogenic and procoagulant factors, and also stimulate other cells to express various components promoting emerging thromboinflammation. The discovery of neutrophil extracellular traps (NETs) provides an opportunity to take a new look at biology and a role neutrophils may play in thromboinflammation and tumorigenesis. The close interplay between tumor cells, tumor-associated neutrophils and NETs as well as other players in the tumor microenvironment underlies activation of thromboinflammation in cancer patients not only resulting in thrombus formation, but also promoting tumor growth and dissemination.

Publisher

IRBIS

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