The role of the microenvironment in tumor growth and spreading-Reference-Cited by-同舟云学术

The role of the microenvironment in tumor growth and spreading

Published:2024-03-06 Issue:1 Volume:18 Page:96-111
ISSN:2500-3194
Container-title:Obstetrics, Gynecology and Reproduction
language:
Short-container-title:Akušerstvo, ginekologiâ i reprodukciâ

Author:

Bitsadze V. О.¹^ORCID,Slukhanchuk Е. V.¹^ORCID,Solopova А. G.¹^ORCID,Khizroeva J. Kh.¹^ORCID,Yakubova F. E.¹^ORCID,Orudzhova Е. А.²,Degtyareva N. D.¹^ORCID,Egorova Е. S.¹^ORCID,Makatsariya N. А.¹^ORCID,Samburova N. V.¹,Serov V. N.³^ORCID,Ashrafyan L. А.³^ORCID,Aslanova Z. D.¹^ORCID,Lazarchuk А. V.¹^ORCID,Kudryavtseva Е. S.¹^ORCID,Solopova А. Е.⁴^ORCID,Kapanadze D. L.⁵,Gris J.-C.⁶^ORCID,Elalamy I.⁷^ORCID,Ay С.⁸,Makatsariya А. D.¹^ORCID

Affiliation:

1. Sechenov University

2. Maternity Hospital No. 1 – Branch of Vorokhobov City Clinical Hospital No. 67 Moscow City Healthcare Department

3. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Health Ministry of Russian Federation

4. Sechenov University; Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Health Ministry of Russian Federation

5. Center for Pathology of Pregnancy and Hemostasis

6. Sechenov University; Montpellier University

7. Sechenov University; Medicine Sorbonne University; Hospital Tenon

8. University of Vienna

Abstract

Introduction. The tumor microenvironment (TME) consisting of non-tumor cells and other components plays a crucial role in cancer development by promoting uncontrolled tumor growth.Aim: to detail all the components in TME and their contribution to carcinogenesis by analyzing available publications.Results. Currently, TME study is of great interest in the medical field. Its crucial role in the tumor initiation, progression, and spreading is emphasized. Several constituents have been identified in TME including cancer-associated fibroblasts, neutrophils, adipocytes, tumor vasculature, lymphocytes, extracellular matrix, dendritic cells, neutrophil extracellular traps, etc. Thromboinflammatory reactions are also considered an important TME element.Conclusion. TME constituents can serve as new targets for both diagnostics and antitumor therapy.

Publisher

IRBIS

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