Neutrophil Extracellular Traps Kill Bacteria-Reference-Cited by-同舟云学术

Neutrophil Extracellular Traps Kill Bacteria

Published:2004-03-05 Issue:5663 Volume:303 Page:1532-1535
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Brinkmann Volker¹²³,Reichard Ulrike¹²³,Goosmann Christian¹²³,Fauler Beatrix¹²³,Uhlemann Yvonne¹²³,Weiss David S.¹²³,Weinrauch Yvette¹²³,Zychlinsky Arturo¹²³

Affiliation:

1. Microscopy Core Facility, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany.

2. Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany.

3. Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

Abstract

Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome. Here, we describe that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria. These neutrophil extracellular traps (NETs) degrade virulence factors and kill bacteria. NETs are abundant in vivo in experimental dysentery and spontaneous human appendicitis, two examples of acute inflammation. NETs appear to be a form of innate response that binds microorganisms, prevents them from spreading, and ensures a high local concentration of antimicrobial agents to degrade virulence factors and kill bacteria.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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