Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38-Reference-Cited by-同舟云学术

Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38

Published:2023-06-10 Issue:15 Volume:180 Page:1899-1929
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:British J Pharmacology

Author:

Armstrong Jane F.¹^ORCID,Campo Brice²,Alexander Stephen P. H.³^ORCID,Arendse Lauren B.⁴,Cheng Xiu⁵,Davenport Anthony P.⁶,Faccenda Elena¹,Fidock David A.⁷⁸,Godinez‐Macias Karla P.⁹,Harding Simon D.¹^ORCID,Kato Nobutaka⁵,Lee Marcus C. S.¹⁰,Luth Madeline R.¹¹,Mazitschek Ralph¹²,Mittal Nimisha¹³,Niles Jacquin C.¹⁴,Okombo John⁷,Ottilie Sabine¹¹,Pasaje Charisse Flerida A.¹⁴^ORCID,Probst Alexandra S.¹⁵,Rawat Mukul¹⁰,Rocamora Frances¹¹,Sakata‐Kato Tomoyo⁵,Southan Christopher¹,Spedding Michael¹⁶^ORCID,Tye Mark A.¹²,Yang Tuo¹⁷,Zhao Na⁵,Davies Jamie A.¹

Affiliation:

1. Deanery of Biomedical Sciences The University of Edinburgh Edinburgh UK

2. Medicines for Malaria Venture Geneva Switzerland

3. School of Life Sciences University of Nottingham Medical School Nottingham UK

4. Drug Discovery and Development Centre (H3D), South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, and Institute of Infectious Disease and Molecular Medicine University of Cape Town Cape Town South Africa

5. Global Health Drug Discovery Institute Beijing China

6. Experimental Medicine and Immunotherapeutics University of Cambridge Cambridge UK

7. Department of Microbiology and Immunology Columbia University Irving Medical Center New York New York USA

8. Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine Columbia University Irving Medical Center New York New York USA

9. Bioinformatics and Systems Biology Graduate Program University of California, San Diego (UCSD) La Jolla California USA

10. Parasites and Microbes Programme Wellcome Sanger Institute Hinxton UK

11. Department of Pediatrics University of California San Diego School of Medicine La Jolla California USA

12. Center for Systems Biology Massachusetts General Hospital Boston Massachusetts USA

13. Thermo Fisher Scientific San Diego California USA

14. Department of Biological Engineering Massachusetts Institute of Technology Cambridge Massachusetts USA

15. Department of Immunology and Infectious Diseases Harvard TH Chan School of Public Health Boston Massachusetts USA

16. Spedding Research Solutions SAS Le Vésinet France

17. Department of Pediatrics, School of Medicine University of California, San Diego La Jolla California USA

Abstract

Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target‐based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.

Funder

British Pharmacological Society

Medicines for Malaria Venture

Publisher

Wiley

Subject

Pharmacology

Link

https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bph.16144

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