Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l -proline

Author:

Adachi Ryutaro,Okada Kengo,Skene Robert,Ogawa Kazumasa,Miwa Masanori,Tsuchinaga Kazuhiro,Ohkubo Shoichi,Henta Tsutomu,Kawamoto Tomohiro

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference20 articles.

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2. S.G. Park, P. Schimmel, S. Kim, A.M. Lambowitz, Aminoacyl tRNA synthetases and their connections to disease, (n.d.)..

3. The chemistry and biology of febrifugine and halofuginone;McLaughlin;Bioorg. Med. Chem.,2014

4. Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase;Keller;Nat. Chem. Biol.,2012

5. Halofuginone: a novel antifibrotic therapy;Pines;Gen. Pharmacol.,1998

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