A Framework that Considers the Impacts of Time, Cost, and Uncertainty in the Determination of the Cost Effectiveness of Toxicity‐Testing Methodologies

Author:

Price Paul S.1ORCID,Hubbell Bryan J.2,Hagiwara Shintaro34,Paoli Greg M.4,Krewski Daniel5,Guiseppi‐Elie Annette1,Gwinn Maureen R.6,Adkins Norman L.1,Thomas Russell S.1

Affiliation:

1. Center for Computational Toxicology and Exposure US Environmental Protection Agency, Research Triangle Park Durham NC USA

2. Air, Climate, and Energy Research Program US Environmental Protection Agency, Research Triangle Park Durham NC USA

3. School of Mathematics and Statistics Carleton University Ottawa Canada

4. Risk Sciences International Ottawa Canada

5. McLaughlin Centre for Population Health Risk Assessment University of Ottawa Ottawa Canada

6. Sustainable and Healthy Communities Research Program US Environmental Protection Agency, Research Triangle Park NC USA

Publisher

Wiley

Subject

Physiology (medical),Safety, Risk, Reliability and Quality

Reference40 articles.

1. Food for thought… on the economics of animal testing;Bottini A. A.;ALTEX‐Alternatives to animal experimentation,2009

2. The comparative cost‐effectiveness of statistical decision rules and experienced physicians in pharyngitis management;Cebul R. D.;JAMA,1986

3. 2012 Council of Canadian Academies Ottawa Canada CCA: Council of Canadian Academies. Integrating emerging technologies into chemical safety assessment. Expert panel on the integrated testing of pesticides

4. Beyond the RfD: Broad Application of a Probabilistic Approach to Improve Chemical Dose–Response Assessments for Noncancer Effects

5. A Unified Probabilistic Framework for Dose–Response Assessment of Human Health Effects

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