Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers-Reference-Cited by-同舟云学术

Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers

Published:2021-11-07 Issue:1 Volume:15 Page:79-91
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clinical Translational Sci

Author:

Yoshida Kosuke¹²^ORCID,Doi Yuki¹^ORCID,Iwazaki Norihiko¹^ORCID,Yasuhara Hidenori¹^ORCID,Ikenaga Yuka¹,Shimizu Hidetoshi¹^ORCID,Nakada Tomohisa¹^ORCID,Watanabe Tomoko¹^ORCID,Tateno Chise³^ORCID,Sanoh Seigo²^ORCID,Kotake Yaichiro²^ORCID

Affiliation:

1. DMPK Research Laboratories Sohyaku Innovative Research Division Mitsubishi Tanabe Pharma Corporation Kanagawa Japan

2. Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan

3. Research and Development Department PhoenixBio Co., Ltd. Hiroshima Japan

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13070

Reference33 articles.

1. Addressing the Challenges of Low Clearance in Drug Research

2. Use of HμREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds

3. Accelerated drug discovery by rapid candidate drug identification

4. Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice

5. EXPRESSION OF HUMAN CYTOCHROMES P450 IN CHIMERIC MICE WITH HUMANIZED LIVER

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