Use of HμREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds
Author:
Affiliation:
1. Drug Safety & Metabolism and §RIA iMed DMPK, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.6b00396
Reference36 articles.
1. Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985).
2. Can the pharmaceutical industry reduce attrition rates?
3. Addressing the Challenges of Low Clearance in Drug Research
4. Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View
5. Predicting Clearance in Humans from In Vitro Data
Cited by 46 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Comparison of Human Long-Term Liver Models for Clearance Prediction of Slowly Metabolized Compounds;DRUG METAB DISPOS;2024
2. Comparison of Human Long-Term Liver Models for Clearance Prediction of Slowly Metabolized Compounds;Drug Metabolism and Disposition;2024-04-11
3. Aminobenzotriazole inhibits and induces several key drug metabolizing enzymes complicating its utility as a pan CYP inhibitor for reaction phenotyping;Clinical and Translational Science;2024-03
4. Use of Human Intestinal and Hepatic Tissue Fractions and Microbiome as Models in Assessment of Drug Metabolism and its Impact on Oral Bioavailability;Oral Bioavailability and Drug Delivery;2023-10-10
5. Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation;Drug Metabolism and Disposition;2023-09-26
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3