Addressing the Challenges of Low Clearance in Drug Research
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science
Link
http://link.springer.com/content/pdf/10.1208/s12248-014-9691-7.pdf
Reference22 articles.
1. Roffey SJ, Obach RS, Gedge JI, Smith DA. What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs. Drug Metab Rev. 2007;39(1):17–43.
2. Di L, Kerns EH, Ma XJ, Huang Y, Carter GT. Applications of high throughput microsomal stability assay in drug discovery. Comb Chem High Throughput Screen. 2008;11(6):469–76.
3. Hop CECA, Cole MJ, Davidson RE, Duignan DB, Federico J, Janiszewski JS, et al. High throughput ADME screening: practical considerations, impact on the portfolio and enabler of in silico ADME models. Curr Drug Metab. 2008;9(9):847–53.
4. Rudewicz PJ, Yue Q, Shin Y. High-throughput strategies for metabolite identification in drug discovery. High-Throughput Analysis in the Pharmaceutical Industry. 2009;141–54
5. Di L, Kerns EH, Carter GT. Drug-like property concepts in pharmaceutical design. Curr Pharm Des. 2009;15(19):2184–94.
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