Enantiospecific pharmacokinetics of intravenous dexmedetomidine in beagles

Author:

Levionnois Olivier Louis1ORCID,Barbarossa Andrea2ORCID,Bardhi Anisa2ORCID,Siegenthaler Joelle1,Forss Pleyers Tekla1ORCID,Guidi Monia34ORCID,Spadavecchia Claudia1ORCID,Raillard Mathieu1ORCID

Affiliation:

1. Section of Anaesthesiology and Pain Therapy, Department of Clinical Veterinary Sciences, Vetsuisse Faculty University of Bern Bern Switzerland

2. Department of Veterinary Medical Sciences Alma Mater Studiorum – University of Bologna Bologna Italy

3. Service of Clinical Pharmacology, Department of Laboratory Medicine and Pathology Lausanne University Hospital and University of Lausanne Lausanne Switzerland

4. Center for Research and Innovation in Clinical Pharmaceutical Sciences, Teaching and Research Department Lausanne University Hospital and University of Lausanne Lausanne Switzerland

Publisher

Wiley

Subject

General Veterinary,Pharmacology

Reference21 articles.

1. A quick approach for medetomidine enantiomer determination in dog plasma by chiral liquid chromatography–tandem mass spectrometry and application to a pharmacokinetic study

2. Effects of MK-467 on the antinociceptive and sedative actions and pharmacokinetics of medetomidine in dogs

3. Drug disposition in three dimensions: an update on stereoselectivity in pharmacokinetics

4. Assessment of intrasubject variability of pharmacokinetic parameters in clinical studies;Chang C.;Therapeutic Innovation & Regulatory Science,1997

5. EMA. (2011).Guideline on bioanalytical method validation. EMEA/CHMP/EWP/192217/2009. European Medicine Agency.https://www.ema.europa.eu/en/documents/scientific‐guideline/guideline‐bioanalytical‐method‐validation_en.pdf

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