Effects of MK-467 on the antinociceptive and sedative actions and pharmacokinetics of medetomidine in dogs

Author:

Bennett R. C.12,Salla K. M.2,Raekallio M. R.2,Hänninen L.3,Rinne V. M.4,Scheinin M.4,Vainio O. M.2ORCID

Affiliation:

1. University Veterinary Hospital; UCD; Dublin Ireland

2. Department of Equine and Small Animal Medicine; University of Helsinki; Helsinki Finland

3. Department of Production Animal Medicine; University of Helsinki; Helsinki Finland

4. Department of Pharmacology; Drug Development and Therapeutics; University of Turku and Unit of Clinical Pharmacology; Turku University Hospital; Turku Finland

Funder

Eläinlääketieteen Tutkimuksen Tukisäätiö

ANIWEL graduate school

Publisher

Wiley

Subject

General Veterinary,Pharmacology

Reference32 articles.

1. Correlation between serum concentrations following continuous intravenous infusion of dexmedetomidine or medetomidine in cats and their sedative and analgesic effects;Ansah;Journal of Veterinary Pharmacology and Therapeutics,1997

2. Characterisation of the cardiovascular pharmacology of medetomidine in the horse and sheep;Bryant;Research in Veterinary Science,1998

3. Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat;Buerkle;British Journal of Anaesthesia,1998

4. A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066;Clineschmidt;Journal of Pharmacology and Experimental Therapeutics,1988

5. Influence of cardiac output on dexmedetomidine pharmacokinetics;Dutta;Journal of Pharmaceutical Sciences,2000

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