A quick approach for medetomidine enantiomer determination in dog plasma by chiral liquid chromatography–tandem mass spectrometry and application to a pharmacokinetic study-Reference-Cited by-同舟云学术

A quick approach for medetomidine enantiomer determination in dog plasma by chiral liquid chromatography–tandem mass spectrometry and application to a pharmacokinetic study

Published:2021-02-23 Issue:7 Volume:13 Page:1249-1255
ISSN:1942-7603
Container-title:Drug Testing and Analysis
language:en
Short-container-title:Drug Test Anal

Author:

Bardhi Anisa¹,Zaghini Anna¹,Levionnois Olivier²,Barbarossa Andrea¹^ORCID

Affiliation:

1. Department of Veterinary Medical Sciences Alma Mater Studiorum ‐ University of Bologna Bologna Italy

2. Unit of Anaesthesiology and Pain therapy, Department for Clinical Veterinary Science, Faculty Vetsuisse University of Bern Bern Switzerland

Publisher

Wiley

Subject

Spectroscopy,Pharmaceutical Science,Environmental Chemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/dta.3015

Reference10 articles.

1. Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist

2. Comparison of the behavioural and neurochemical effects of the two optical enantiomers of medetomidine, a selective alpha‐2‐adrenoceptor agonist;MacDonald E;J Pharmacol Exp Ther,1991

3. A review of the physiological effects of alpha‐2‐aginists related to the clinical use of medetomidine in small animal practice;Sinclair MD;Can Vet J,2003

4. Central α2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine

5. Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs

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1. Development of an electrochemical medetomidine nanosensor based on N and P-doped carbon nano-onions, MoS2, and poly (melamine) nanocomposite;Microchemical Journal;2023-07

2. Development and validation of a chiral LC-MS method for the enantiomeric resolution of (+) and (-)-Mebeverine Hydrochloride in bulk drug by using polysaccharide-based chiral stationary phase;Analytical Chemistry Letters;2023-05-04

3. Enantiospecific pharmacokinetics of intravenous dexmedetomidine in beagles;Journal of Veterinary Pharmacology and Therapeutics;2022-04-29