1. Department of Pharmacy; Ingá Faculty; 87035-510 Maringa Brazil
2. Laboratory of Toxicology; Department of Basic Health Sciences; State University of Maringa (UEM); Colombo Avenue 5790 87020-900 Maringa Brazil
3. Department of Clinical Analysis and Biomedicine; State University of Maringa (UEM), Colombo Avenue 5790; 87020-900 Maringa, Brazil