Discovery of New Sites for Drug Binding to the Hypertension-Related Renin-Angiotensinogen Complex-Reference-Cited by-同舟云学术

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Discovery of New Sites for Drug Binding to the Hypertension-Related Renin-Angiotensinogen Complex

Published:2014-03-18 Issue:4 Volume:83 Page:427-439
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Brás Natércia F.¹,Fernandes Pedro A.¹,Ramos Maria J.¹

Affiliation:

1. REQUIMTE; Departamento de Química e Bioquímica; Faculdade de Ciências; Universidade do Porto; Rua do Campo Alegre s/n 4169-007 Porto Portugal

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12258/fullpdf

Reference47 articles.

1. Aliskiren: the first renin inhibitor for clinical treatment;Jensen;Nat Rev Drug Discov,2008

2. Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors;Bezencon;J Med Chem,2009

3. Aspartic proteinases in disease: a structural perspective;Cooper;Curr Drug Targets,2002

4. Optimization of orally bioavailable alkyl amine renin inhibitors;Xu;Bioorg Med Chem Lett,2010

5. The catalytic mechanism of mouse renin studied with QM/MM calculations;Bras;Phys Chem Chem Phys,2012

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