Disruption of protein–protein interactions: hot spot detection, structure-based virtual screening and in vitro testing for the anti-cancer drug target

Disruption of protein–protein interactions: hot spot detection, structure-based virtual screening and in vitro testing for the anti-cancer drug target – survivin

Published:2016 Issue:38 Volume:6 Page:31947-31959
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sarvagalla Sailu¹²³⁴⁵,Cheung Chun Hei Antonio⁶⁷⁸⁹¹⁰,Tsai Ju-Ya⁶⁷⁸⁹¹⁰,Hsieh Hsing Pang¹¹¹²¹³¹⁰,Coumar Mohane Selvaraj¹²³⁴⁵

Affiliation:

1. Centre for Bioinformatics

2. School of Life Sciences

3. Pondicherry University

4. Puducherry 605014

5. India

6. Department of Pharmacology

7. College of Medicine

8. National Cheng Kung University

9. Tainan

10. Republic of China

11. Institute of Biotechnology and Pharmaceutical Research

12. National Health Research Institutes

13. Miaoli County 350

Abstract

Hot spot detection at the protein–protein interaction interface using computational tools helped to identify indinavir as survivin inhibitor.

Funder

Department of Biotechnology , Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA22927H

Reference68 articles.

1. Protein-Protein Interactions and Prediction: A Comprehensive Overview

2. Stabilized Helical Peptides: A Strategy to Target Protein–Protein Interactions

3. Protein–protein interactions in human disease

4. Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

5. Targeting protein–protein interactions for cancer therapy

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