α2-Adrenoceptor-blocking action of the phenylethanolamine-N-methyltransferase inhibitor SKF 64139
Author:
Affiliation:
1. Department of Pharmacology, Glaxo Group Research, Ware, Hertfordshire, SG12 0DJ, UK
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Link
http://academic.oup.com/jpp/article-pdf/33/1/187/37770097/j.2042-7158.1981.tb13750.x.pdf
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1. Comparison of the Binding of 3-Fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with Their Isosteric Sulfonamides to the Active Site of Phenylethanolamine N-Methyltransferase;Journal of Medicinal Chemistry;2006-08-11
2. Application of the Goldilocks Effect to the Design of Potent and Selective Inhibitors of Phenylethanolamine N-Methyltransferase: Balancing pKa and Steric Effects in the Optimization of 3-Methyl-1,2,3,4-tetrahydroisoquinoline Inhibitors by β-Fluorination;Journal of Medicinal Chemistry;2006-04-14
3. Modulatory Role of the Epinergic System in the Neuroendocrine-Immune System Function;Neuroimmunomodulation;2000
4. Enantiospecific Synthesis of 3-Fluoromethyl-, 3-Hydroxymethyl-, and 3-Chloromethyl-1,2,3,4-tetrahydroisoquinolines as Selective Inhibitors of Phenylethanolamine N-Methyltransferase versus the α2-Adrenoceptor;Journal of Medicinal Chemistry;1999-10-01
5. Synthesis and Evaluation of 3-Trifluoromethyl-7-substituted- 1,2,3,4-tetrahydroisoquinolines as Selective Inhibitors of Phenylethanolamine N-Methyltransferase versus the α2-Adrenoceptor;Journal of Medicinal Chemistry;1999-08-01
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