The Use of a Radiolabelled Saccharin Solution to Monitor the Effect of the Preservatives Thiomersal, Benzalkonium Chloride and EDTA on Human Nasal Clearance-Reference-Cited by-同舟云学术

The Use of a Radiolabelled Saccharin Solution to Monitor the Effect of the Preservatives Thiomersal, Benzalkonium Chloride and EDTA on Human Nasal Clearance

Published:1991-03 Issue:3 Volume:43 Page:180-185
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Batts Alison H¹,Marriott Christopher¹,Martin Gary P¹,Bond Steven W²,Greaves Jane L³,Wilson Clive G³

Affiliation:

1. Pharmaceutical Sciences Research Group, Department of Pharmacy, Brighton Polytechnic, Brighton BN2 4GJ

2. Wellcome Foundation Ltd., Dartford, Kent

3. Department of Physiology and Pharmacology, Queen's Medical Centre, Nottingham, UK

Abstract

Abstract The effect of thiomersal, benzalkonium chloride and ethylenediaminetetraacetic acid (EDTA) on the nasal mucociliary clearance of healthy volunteers has been investigated using a modified saccharin test and gamma scintigraphy concomitantly. A significant correlation was found between the two techniques. Using each subject as his/her own control, none of the preservatives significantly altered the rate of clearance or proportion cleared from the nasal cavity after the administration of a single dose. This result is at variance with some in-vitro findings.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/43/3/180/37240839/j.2042-7158.1991.tb06662.x.pdf

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3. Human nasal mucus flow rates;Bang;John Hopkin Med. J.,1967

4. The effect of some preservatives used in nasal preparations on mucociliary clearance;Batts;J. Pharm. Pharmacol.,1989

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