Affiliation:
1. Pharmaceutical Sciences Research Group, Department of Pharmacy, Brighton Polytechnic, Brighton, BN2 4GJ, UK
2. The Wellcome Foundation Ltd., Dartford, Kent, UK
Abstract
Abstract
The effect of methyl-ρ-hydroxybenzoate, propyl-ρ-hydroxybenzoate, chlorbutol, chlorocresol, EDTA, benzalkonium chloride, chlorhexidine, phenylmercuric nitrate and phenylmercuric borate on mucociliary transport rate of the frog palate has been examined. Following a variable number of applications all these preservatives halted transport, the first three reversibly. However, applications of thiomersal (0·01%) were well tolerated. The frog palate possesses a ciliated epithelium protected by mucus, since some of our findings are at variance with those previously reported results where the protective effect of mucus was negligible in the in-vitro model (usually trachea) employed, it would appear that the contribution of mucus to effective mucociliary clearance should not be underestimated.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
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