Nose-to-Brain Targeted Drug Delivery Bypassing the Blood-Brain Barrier

Abstract

The treatment of brain disorders like Alzheimer's, Parkinson's, etc. has been challenging due to a variety of obstacles of effective delivery of the drugs to the brain. Intranasal drug delivery (INDD) is a non-invasive and convenient route of drug intake and hence has been useful for drugs targeting neurological (brain) disorders. This method bypasses the blood-brain barrier (BBB), delivering the medication directly to the brain. The intranasal route is the direct transportation of drugs via the olfactory and trigeminal nerve pathways to the brain overcoming the BBB. An enormous range of macromolecular to micromolecular medications can be delivered to the CNS via this pathway. INDDS offers a non-invasive, safe, and convenient route of direct drug administration to the brain and increasing the bioavailability of the drug. Bypassing the BBB is an important factor due to the low permeability of some drugs, and INDDS helps overcome this barrier.