A guide to enzyme kinetics in early drug discovery
Author:
Affiliation:
1. Mechanistic and Structural Biology Discovery Sciences R&D AstraZeneca Cambridge UK
Publisher
Wiley
Subject
Cell Biology,Molecular Biology,Biochemistry
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/febs.16404
Reference57 articles.
1. Kinetics for Drug Discovery: an industry-driven effort to target drug residence time
2. Drug–Target Kinetics in Drug Discovery
3. Structure–Kinetic Relationships—An Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists
4. The Role of Target Binding Kinetics in Drug Discovery
5. The importance of target binding kinetics for measuring target binding affinity in drug discovery: a case study from a CRF1 receptor antagonist program
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