Structure–Kinetic Relationships—An Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists-Reference-Cited by-同舟云学术

Structure–Kinetic Relationships—An Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists

Published:2013-09-27 Issue:19 Volume:56 Page:7706-7714
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vilums Maris¹,Zweemer Annelien J. M.¹,Yu Zhiyi¹,de Vries Henk¹,Hillger Julia M.¹,Wapenaar Hannah¹,Bollen Ilse A. E.¹,Barmare Farhana²,Gross Raymond²,Clemens Jeremy²,Krenitsky Paul²,Brussee Johannes¹,Stamos Dean²,Saunders John²,Heitman Laura H.¹,IJzerman Adriaan P.¹

Affiliation:

1. Division of Medicinal Chemistry, Leiden Academic Center for Drug Research, Leiden University, Post Office Box 9502, 2300 RA Leiden, Netherlands

2. Vertex Pharmaceuticals, Incorporated, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4011737

Reference35 articles.

1. The Many Roles of Chemokines and Chemokine Receptors in Inflammation

2. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2