Inhibition of <i>Salmonella typhimurium</i> infection in mice fed with live or heat‐killed <i>Lactiplantibacillus plantarum</i> MWFLp‐182-Reference-Cited by-同舟云学术

Inhibition of Salmonella typhimurium infection in mice fed with live or heat‐killed Lactiplantibacillus plantarum MWFLp‐182

Published:2024-08-27 Issue: Volume: Page:
ISSN:1364-727X
Container-title:International Journal of Dairy Technology
language:en
Short-container-title:Int J of Dairy Tech

Author:

Liu Jia¹²,Sun Peng¹²,Jin Zihan¹,Nie Hui¹²³,Mu Guangqing¹²^ORCID,Wu Xiaomeng¹²^ORCID

Affiliation:

1. School of Food Science and Technology Dalian Polytechnic University Dalian 116034 China

2. Dalian Probiotic Function Research Key Laboratory Dalian Polytechnic University Dalian 116034 China

3. Guangxi Key Laboratory of Health Care Food Science and Technology Hezhou University Hezhou Guangxi 542899 China

Abstract

The effects of both live and heat‐killed states of Lactiplantibacillus plantarum MWFLp‐182 (L. plantarum MWFLp‐182) isolated from the faeces of long‐lived humans on preventing and relieving Salmonella infection were studied. Evaluation methods included RT‐qPCR measurement of inflammatory factors, histopathological analysis and non‐targeted metabolomics. The results showed that L. plantarum MWFLp‐182 in both states improved body weight loss, organ swelling and ileocolon pathological damage. They also protected against Salmonella infection by regulating key KEGG enrichment pathways and the expression levels of TNF‐a and IL‐6. It is worth noting that the function of live bacteria was better than that of heat‐killed bacteria.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/1471-0307.13131

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