Blocking glutamate mGlu 5 receptors with the negative allosteric modulator CTEP improves disease course in SOD1 G93A mouse model of amyotrophic lateral sclerosis

Author:

Milanese Marco12,Bonifacino Tiziana12,Torazza Carola1,Provenzano Francesca13,Kumar Mandeep1,Ravera Silvia4,Zerbo Arianna Roberta1,Frumento Giulia1,Balbi Matilde1,Nguyen T. P. Nhung1,Bertola Nadia4,Ferrando Sara5,Viale Maurizio6,Profumo Aldo6,Bonanno Giambattista16

Affiliation:

1. Department of Pharmacy, Pharmacology and Toxicology Unit University of Genoa Genoa Italy

2. Inter‐University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R) Genoa Italy

3. Department of Neurodegenerative Diseases Hertie Institute for Clinical Brain Research, University of Tübingen and German Center for Neurodegenerative Diseases (DZNE) Tübingen Germany

4. Department of Experimental Medicine University of Genoa Genoa Italy

5. Department of Earth, Environmental and Life Science University of Genoa Genoa Italy

6. IRCCS Ospedale policlinico San Martino Genoa Italy

Funder

Ministero della Salute

Publisher

Wiley

Subject

Pharmacology

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