Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner-Reference-Cited by-同舟云学术

Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner

Published:2020-12-15 Issue:662 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Abd-Elrahman Khaled S.¹²³^ORCID,Albaker Awatif¹²⁴,de Souza Jessica M.¹²⁵,Ribeiro Fabiola M.⁵^ORCID,Schlossmacher Michael G.¹²⁶⁷^ORCID,Tiberi Mario¹²⁶⁷⁸^ORCID,Hamilton Alison¹²,Ferguson Stephen S. G.¹²^ORCID

Affiliation:

1. University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario K1H 8M5, Canada.

2. Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

3. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

4. Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 12371, Saudi Arabia.

5. Department of Biochemistry and Immunology, ICB, Universidade Federalde Minas Gerais, Belo Horizonte 31270-901, Brazil.

6. Department of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

7. Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario, K1H 8L6, Canada

8. Department of Psychiatry, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

Abstract

A sex-specific prion-amyloid interaction predicts that some Alzheimer’s disease therapies may not work in female patients.

Funder

Canadian Institutes of Health Research

Krembil Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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