A New Water-soluble Camptothecin Derivative, DX-8951f, Exhibits Potent Antitumor Activity against Human Tumorsin vitroandin vivo

Author:

Mitsui Ikuo,Kumazawa Eiji,Hirota Yasuhide,Aonuma Masashi,Sugimori Masamichi,Ohsuki Satoru,Uoto Kouichi,Ejima Akio,Terasawa Hirofumi,Sato Keiki

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference30 articles.

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2. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I;Hsiang;J. Biol Chem.,1985

3. Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin;Hsiang;Cancer Res.,1988

4. On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex;Hertzberg;Biochemistry,1989

5. Studies on the antitumor activity, mechanism of action, and cell cycle effects of camptothecin;Gallo;J. Natl. Cancer Inst.,1971

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