Route Design and Scale-Up of a Topoisomerase I Inhibitor Antibody–Drug Conjugate Payload-Reference-Cited by-同舟云学术

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Route Design and Scale-Up of a Topoisomerase I Inhibitor Antibody–Drug Conjugate Payload

Published:2024-06-11 Issue:6 Volume:28 Page:2355-2366
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Goundry William R. F.¹,Poulton Andrew M.¹,Welham Matthew²,Dai Kuangchu³,Zhu Xiaohong³,Tao Haijun³,Tang Canlin³,Magne Fanny⁴,Cottineau Bertrand⁴

Affiliation:

1. Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, U.K.

2. Process Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, U.K.

3. Changzhou SynTheAll Pharmaceutical Co. Ltd, No 589 North Yulong Road, Chunjiang Town, Xinbei District, Changzhou, Jiangsu 213127, P. R. China

4. Axplora, 1 Rue Démocrite, 72000 Le Mans, France

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00175

Reference11 articles.

1. Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

2. Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

3. A New Water-soluble Camptothecin Derivative, DX-8951f, Exhibits Potent Antitumor Activity against Human Tumorsin vitroandin vivo

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