The anticonvulsant and behavioural profile of L-687,414, a partial agonist acting at the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex

Author:

Tricklebank M.D.,Bristow L.J.,Hutson P.H.,Leeson P.D.,Rowley M.,Saywell K.,Singh L.,Tattersall F.D.,Thorn L.,Williams B.J.

Publisher

Wiley

Subject

Pharmacology

Reference31 articles.

1. The dissociative anaesthetics, ketamine and PCP, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate;ANIS;Br. J. Pharmacol.,1983

2. The discriminative stimulus properties of the glycine/NMDA receptor antagonist, L, 687, 414;BOURSON;Fund. Clin. Pharmacol.,1991

3. The glycine/NMDA receptor antagonist, R-(+)-H A-966, blocks activation of the mesolimbic dopaminergic system induced by PCP and dizocilpine (MK-801) in rodents;BRISTOW;Br. J. Pharmacol.,1993

4. Evidence for involvement of brain dopamine and other mechanisms in the behavioral action of the N-methyl-D-aspartic acid antagonist MK-801 in control and 6-hydroxydopamine-lesioned rats;CRISWELL;J. Pharmacol Exp. Ther.,1993

5. CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity;VIES;Brain Res.,1986

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