Violacein and its antifungal activity: comments and potentialities

Author:

Durán N.12,Castro G.R.23,Portela R.W.D.4,Fávaro W.J.1,Durán M.1,Tasic L.5,Nakazato G.6ORCID

Affiliation:

1. Laboratory of Urogenital Carcinogenesis and Immunotherapy, Department of Structural and Functional Biology Universidade Estadual de Campinas (UNICAMP) Campinas SP Brazil

2. Nanomedicine Research Unit (Nanomed), Center for Natural and Human Sciences (CCNH) Universidade Federal do ABC (UFABC) Santo André SP Brazil

3. Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario (MPLbioR, UNR-MPIbpC). Partner Laboratory of the Max Planck Institute for Biophysical Chemistry (MPIbpC, MPG) Centro de Estudios Interdisciplinarios (CEI), Universidad Nacional de Rosario Rosario Santa Fe Argentina

4. Laboratory of Immunology and Molecular Biology Health Sciences Institute, Universidade Federal da Bahia Salvador BA Brazil

5. Biogical Chemistry Laboratory Institute of Chemistry, Universidade Estadual de Campinas (UNICAMP) Campinas SP Brazil

6. Laboratory of Basic and Applied Bacteriology, Department of Microbiology, Biology Sciences Center Universidade Estadual de Londrina (UEL) Londrina Puerto Rico Brazil

Abstract

Abstract Violacein is an important natural antimicrobial pigment that is mainly produced by Chromobacterium violaceum and Janthinobacterium lividum. It presents a significant range of effects against phytopathogenic and human fungi, besides being featured as having low toxicity, and by its important ecological role in protecting amphibian species and applications in dyed medical fabric. The hypothesis about violacein's action mechanisms against mucormycosis (Rhizopus arrhizus) and candidiasis (Candida auris) is herein discussed based on data available in the scientific literature.

Publisher

Oxford University Press (OUP)

Subject

Applied Microbiology and Biotechnology

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