Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases ?-cleavage of amyloid precursor protein and amyloid-? production in vivo-Reference-Cited by-同舟云学术

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases ?-cleavage of amyloid precursor protein and amyloid-? production in vivo

Published:2007-02 Issue:3 Volume:100 Page:802-809
ISSN:0022-3042
Container-title:Journal of Neurochemistry
language:en
Short-container-title:J Neurochem

Author:

Hussain Ishrut,Hawkins Julie,Harrison David,Hille Christopher,Wayne Gareth,Cutler Leanne,Buck Tania,Walter Daryl,Demont Emmanuel,Howes Colin,Naylor Alan,Jeffrey Philip,Gonzalez Maria I.,Dingwall Colin,Michel Anton,Redshaw Sally,Davis John B.

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1471-4159.2006.04260.x/fullpdf

Reference37 articles.

1. The novel β-secretase inhibitor KMI-429 reduces amyloid β peptide production in amyloid precursor protein transgenic and wild-type mice

2. BACE1 is the major β-secretase for generation of Aβ peptides by neurons

3. In vivo inhibition of Aβ production by memapsin 2 (β‐secretase) inhibitors

4. Characterization of the Glycosylation Profiles of Alzheimer's β-Secretase Protein Asp-2 Expressed in a Variety of Cell Lines

5. Exclusively targeting -secretase to lipid rafts by GPI-anchor addition up-regulates -site processing of the amyloid precursor protein

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