In vivo inhibition of Aβ production by memapsin 2 (β‐secretase) inhibitors-Reference-Cited by-同舟云学术

In vivo inhibition of Aβ production by memapsin 2 (β‐secretase) inhibitors

Published:2004-05-07 Issue:6 Volume:89 Page:1409-1416
ISSN:0022-3042
Container-title:Journal of Neurochemistry
language:en
Short-container-title:Journal of Neurochemistry

Author:

Chang Wan‐Pin¹,Koelsch Gerald¹²,Wong Stephen³,Downs Deborah¹,Da Huining¹,Weerasena Vajira¹²,Gordon Brian⁴,Devasamudram Thippeswamy¹,Bilcer Geoffrey²,Ghosh Arun K.⁵,Tang Jordan¹⁶

Affiliation:

1. Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

2. Zapaq, Inc., Oklahoma City, Oklahoma, USA

3. College of Medicine, University of Oklahoma, Oklahoma City, Oklahoma, USA

4. Department of Comparative Medicine, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

5. Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois, USA

6. Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.2004.02452.x

Reference27 articles.

1. BACE1 is the major β-secretase for generation of Aβ peptides by neurons

2. Peripheral anti-A antibody alters CNS and plasma A clearance and decreases brain A burden in a mouse model of Alzheimer's disease

3. Brain to Plasma Amyloid-β Efflux: a Measure of Brain Amyloid Burden in a Mouse Model of Alzheimer's Disease

4. Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

5. Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease

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