Discrete phase model of blood flow in a roughness microchannel simulating the formation of pseudointima
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Published:2022
Issue:1
Volume:24
Page:
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ISSN:1509-409X
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Container-title:Acta of Bioengineering and Biomechanics
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language:en
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Short-container-title:Acta Bioeng Biomech
Author:
Kopernik Magdalena,Dyrda Karina,Kurtyka Przemysław,Major Roman
Abstract
Purpose: The goal of the present study was the development of discrete phase model to simulate the phenomenon of backfilling a morphologically complex surface by red blood cells (RBCs) in a flow microchannel and to anticipate the conditions of forming a pseudointima. The objective of the experimental studies that inspired the development of the simulation was to create a surface that stimulates the formation of the pseudointima layer. Methods: The finite volume method (FVM) and discrete particle method (DPM) were applied to develop the target model. In addition, a mixture model and a roughness model of bottom layer were tested in the present study to show their influence on simulation the phenomenon of backfilling a morphologically complex surface by RBCs in a flow microchannel. Results: Numerical models were developed including: a) FVM models to compare the effect of applying boundary conditions with/without roughness and cubes, as well as the analysis of their influence on blood velocity and shear stress; b) mixture models to compare the effect of applying different boundary conditions and cubes on computed results; c) DPM models to compare the effect of applying and not applying roughness as a boundary condition; d) DPM models with a morphologically complex surface and RBCs collisions to present RBCs concentration, velocity and time distributions during flow in a channel. Conclusions: The analysis carried out for the developed numerical models indicates that DPM model with cubes computes the best results. It also shows the backfilling of a morphologically complex surface of the bottom microchannel with RBCs.
Publisher
Politechnika Wroclawska Oficyna Wydawnicza
Subject
Biomedical Engineering,Biomaterials,Bioengineering,Biophysics
Cited by
3 articles.
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