Substitutions of Asn-726 in the Active Site of Yeast DNA Topoisomerase I Define Novel Mechanisms of Stabilizing the Covalent Enzyme-DNA Intermediate
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference42 articles.
1. DNA TOPOISOMERASES
2. Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs
3. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme
4. DNA Topoisomerases: Essential Enzymes and Lethal Targets
5. Clinical applications of the camptothecins
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1. A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation;Science Advances;2020-11-13
2. A conserved SUMO-Ubiquitin pathway directed by RNF4/SLX5-SLX8 and PIAS4/SIZ1 drives proteasomal degradation of topoisomerase DNA-protein crosslinks;2019-07-19
3. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations;Journal of Experimental & Clinical Cancer Research;2016-03-31
4. DNA Topoisomerase I Domain Interactions Impact Enzyme Activity and Sensitivity to Camptothecin;Journal of Biological Chemistry;2015-05
5. Tyrosyl-DNA Phosphodiesterase I Catalytic Mutants Reveal an Alternative Nucleophile That Can Catalyze Substrate Cleavage;Journal of Biological Chemistry;2015-03
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