A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation-Reference-Cited by-同舟云学术

A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation

Published:2020-11-13 Issue:46 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Sun Yilun¹²^ORCID,Miller Jenkins Lisa M.³^ORCID,Su Yijun P.⁴,Nitiss Karin C.²^ORCID,Nitiss John L.²^ORCID,Pommier Yves¹^ORCID

Affiliation:

1. Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.

2. Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois, Rockford, IL 61107, USA.

3. Collaborative Protein Technology Resource, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

4. Advanced Imaging and Microscopy Resource, National Institute of Biomedical Imaging and Bioengineering, NIH, MD 20892, USA.

Abstract

A conserved SUMO-ubiquitin-proteasome pathway protects cells from DNA damage induced by topoisomerases.

Funder

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

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2. The DNA-damage response in human biology and disease

3. Mechanisms of DNA–protein crosslink repair

4. Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

5. Substitutions of Asn-726 in the Active Site of Yeast DNA Topoisomerase I Define Novel Mechanisms of Stabilizing the Covalent Enzyme-DNA Intermediate

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