Humanoid shaped optical fiber plasmon biosensor functionalized with graphene oxide/multi-walled carbon nanotubes for histamine detection

Author:

Zhang Wen,Singh Ragini1,Wang Zhi,Li Guoru,Xie YiyanORCID,Jha Rajan2,Marques Carlos3ORCID,Zhang Bingyuan,Kumar SantoshORCID

Affiliation:

1. Liaocheng University

2. Indian Institute of Technology

3. University of Aveiro

Abstract

Histamine is a biologically active molecule that serves as a reliable predictor of the quality of fish. In this work, authors have developed a novel humanoid-shaped tapered optical fiber (HTOF) biosensor based on the localized surface plasmon resonance (LSPR) phenomenon to detect varying histamine concentrations. In this experiment, a novel and distinctive tapering structure has been developed using a combiner manufacturing system and contemporary processing technologies. Graphene oxide (GO)/multi-walled carbon nanotubes (MWCNTs) are immobilized on the HTOF probe surface to increase the biocompatibility of biosensor. In this instance, GO/MWCNTs are deployed first, then gold nanoparticles (AuNPs). Consequently, the GO/MWCNTs help to give abundant space for the immobilization of nanoparticles (AuNPs in this case) as well as increase surface area for the attachment of biomolecules to the fiber surface. By immobilizing AuNPs on the surface of the probe, the evanescent field can stimulate the AuNPs and excite the LSPR phenomena for sensing the histamine. The surface of the sensing probe is functionalized with diamine oxidase enzyme in order to enhance the histamine sensor's particular selectivity. The proposed sensor is demonstrated experimentally to have a sensitivity of 5.5 nm/mM and a detection limit of 59.45 µM in the linear detection range of 0-1000 µM. In addition, the probe's reusability, reproducibility, stability, and selectivity are tested; the results of these indices show that the probe has a high application potential for detecting histamine levels in marine products.

Funder

Double-Hundred Talent Plan of Shandong Province, China

National Natural Science Foundation of China

Special Construction Project Fund for Shandong Province Taishan Mountain Scholars

Natural Science Foundation of Shandong Province

Fundação para a Ciência e a Tecnologia

i3N projects

DigiAqua Project

Publisher

Optica Publishing Group

Subject

Atomic and Molecular Physics, and Optics

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