Exopolysaccharide from Rhodococcus pyridinivorans ZZ47 Strain: Evaluation of Biological Activity and Toxicity
Author:
TAŞKAYA Aylin1ORCID, CEYHAN GÜVENSEN Nur2ORCID, GÜLER Cem3ORCID, ŞANCI Ebru3ORCID, KARABAY Ülkü3ORCID
Affiliation:
1. MUGLA SITKI KOCMAN UNIVERSITY, MUĞLA VOCATIONAL SCHOOL 2. EGE UNIVERSITY, TIRE VOCATIONAL SCHOOL 3. EGE ÜNİVERSİTESİ
Abstract
Microbial polysaccharides are extracellular polymeric macromolecules excreted in microorganisms. These are widely used in food, cosmetic and pharmaceutical industries. One of them, exopolysaccharides (EPS), plays important role against the factors such as phage attack, antibiotics, toxic compounds or osmotic stress. Recently, this natural polymer has received great attention due to their therapeutic potential. The purpose of the study was to evaluate biological activity and potential toxicity of EPS from Rhodococcus pyridinivorans ZZ47 strain isolated from nature. EPS has no genotoxic effect on Salmonella typhimurium TA98, TA102, and TA1537 strains by Ames Test. No death occurred with single dose oral toxicity test of EPS and LD50 value of it is calculated by >2000 mg/kg in mice. The EPS showed antibiofilm activity on different bacteria. In addition, EPS demonstrated dose-dependent anti-angiogenic properties by HET-CAM test. In conclusion, the isolated EPS has antioxidant activity with no genotoxicity and the biological activities of the polymer indicated that it may be suitable for use in different sectors and industrial applications.
Funder
MUĞLA SITKI KOÇMAN ÜNİVERSİTESİ, EGE ÜNİVERSİTESİ
Publisher
Journal of Agricultural Production
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