Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O6-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistance-Reference-Cited by-同舟云学术

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Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O6-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistance

Published:2010-06 Issue:11 Volume:79 Page:1553-1561
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Baumann Raymond P.,Penketh Philip G.,Ishiguro Kimiko,Shyam Krishnamurthy,Zhu Yong L.,Sartorelli Alan C.

Funder

U.S. Public Health Service

National Foundation for Cancer Research

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference30 articles.

1. Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma;Vaupel;Cancer Res.,1981

2. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors;Vaupel;Cancer Res.,1989

3. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects;Höckel;J. Natl. Cancer Inst.,2001

4. Hypoxic gene expression and metastasis;Le;Cancer Metastasis Rev.,2004

5. DNA repair and genetic instability;Bristow;Nature,2008

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4. Physicochemical Considerations of Tumor Selective Drug Delivery and Activity Confinement with Particular Reference to 1,2-Bis(Sulfonyl)-1- Alkylhydrazines Delivery;Current Drug Delivery;2020-07-31

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