NBGNU: a hypoxia-activated tripartite combi-nitrosourea prodrug overcoming AGT-mediated chemoresistance
Author:
Affiliation:
1. Beijing Key Laboratory of Environmental & Virus Oncology, College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, PR China
2. Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Abstract
Publisher
Future Science Ltd
Subject
Drug Discovery,Pharmacology,Molecular Medicine
Link
http://www.future-science.com/doi/pdf/10.4155/fmc-2018-0511
Reference53 articles.
1. Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents
2. 1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of Resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells
3. Anticancer therapies and CNS relapse: overcoming blood–brain and blood–cerebrospinal fluid barrier impermeability
4. Reaction of N-(2-Chloroethyl)-N-nitrosoureas with DNA: Effect of Buffers on DNA Adduction, Cross-Linking, and Cytotoxicity
5. DNA binding and nucleotide flipping by the human DNA repair protein AGT
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