Syntheses of templates derived from pyrrolidine trans -lactams as potential serine protease inhibitors
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference16 articles.
1. Protease Inhibitors: Current Status and Future Prospects
2. Syntheses of trans-5- Oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-Oxo-hexahydro-furo[3,2-b]pyrroles (Pyrrolidine trans-Lactams and trans-Lactones): New Pharmacophores for Elastase Inhibition
3. A Flexible, Practical, and Stereoselective Synthesis of Enantiomerically Pure trans-5-Oxohexahydropyrrolo[3,2-b]pyrroles (Pyrrolidine-trans-lactams), a New Class of Serine Protease Inhibitors, Using Acyliminium Methodology
4. Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine- trans -lactams
5. The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate
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1. A facile approach to α,β-unsaturated lactams by ring-closing metathesis;Chemistry of Heterocyclic Compounds;2016-03
2. De Novo Synthesis of 3-Pyrrolin-2-Ones;Advances in Heterocyclic Chemistry;2015
3. Asymmetric Morita–Baylis–Hillman reaction of isatins with α,β-unsaturated γ-butyrolactam as the nucleophile;RSC Advances;2013
4. A New Tandem Cross Metathesis-Intramolecular Aza-Michael Reaction for the Synthesis of α,α-Difluorinated Lactams;Synthesis;2012-04-27
5. ChemInform Abstract: Syntheses of Templates Derived from Pyrrolidine trans-Lactams as Potential Serine Protease Inhibitors.;ChemInform;2010-05-19
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