Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine- trans -lactams-Reference-Cited by-同舟云学术

Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine- trans -lactams

Published:2001-01 Issue:2 Volume:11 Page:243-246
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Macdonald Simon J.F,Dowle Michael D,Harrison Lee A,Spooner Julie E,Shah Pritom,Johnson Martin R,Inglis Graham G.A,Clarke Geoffrey D.E,Belton David J,Smith Robin A,Molloy Christopher R,Dixon Mary,Murkitt Graham,Godward Rosalind E,Skarzynski Tadeusz,Singh Onkar M.P,Kumar K.Abhhilash,Hodgson Simon T,McDonald Edward,Hardy George W,Finch Harry

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference3 articles.

1. Syntheses of trans-5- Oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-Oxo-hexahydro-furo[3,2-b]pyrroles (Pyrrolidine trans-Lactams and trans-Lactones): New Pharmacophores for Elastase Inhibition

2. Orally Active .beta.-Lactam Inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis and Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones

3. Orally Active Trifluoromethyl Ketone Inhibitors of Human Leukocyte Elastase

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