Kinetic model-aided process optimization via integrated in-situ FTIR and real-time oscillatory shear rheometry: A case study on impurity control and gelation mitigation for a solid phase peptide cleavage process-Reference-Cited by-同舟云学术

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Kinetic model-aided process optimization via integrated in-situ FTIR and real-time oscillatory shear rheometry: A case study on impurity control and gelation mitigation for a solid phase peptide cleavage process

Published:2023-11 Issue: Volume:476 Page:146928
ISSN:1385-8947
Container-title:Chemical Engineering Journal
language:en
Short-container-title:Chemical Engineering Journal

Author:

Wang Jingyao^ORCID,Niemoeller Alexandria^ORCID,Viswanath Shekhar^ORCID

Publisher

Elsevier BV

Subject

Industrial and Manufacturing Engineering,General Chemical Engineering,Environmental Chemistry,General Chemistry

Reference48 articles.

1. Kilogram-scale GMP manufacture of tirzepatide using a hybrid SPPS/LPPS approach with continuous manufacturing;Frederick;Org. Process Res. Dev.,2021

2. Solid phase synthesis;Merrifield;Science,1986

3. Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide;Wang;ACS Omega,2022

4. Development of a Mechanistic Amino Acid Activation Reaction Kinetics Model for Safe and Efficient Solid Phase Peptide Synthesis;Wang;Ind. Eng. Chem. Res.,2023

5. M.D. Johnson, M.E. Kopach, M.R. Berglund, S.R. Groskreutz, J. Wang, L.P. Webster, Three resin reactors in series peptide synthesizer, Google Patents, 2023.

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